Your topic is titled "MISFIRE".....
But you ask about fuel filter.....
Feul filter is in the pump module inside the fuel tank... fuel filter will not cause single cylinder misfires as same pressure in the rail would affect all the cylinders, and typically run out of power/fade out on heavy accell... got codes ?
Single cylinder misfires will come from plugs, wires a whole lot of times (the black plastic end will show signs of arc/burn/lightning strike looks)...
Also look for vacuum leak at intake gasket, real common for gasket to split and leak, throws a mifire code, can of carb or water spray bottle will tell you when vacuum sucks the liquid through the crack..